This one-day virtual symposium updates clinicians on pain science related to challenging conditions. Chronic pain affects about one in four people globally and involves complex biological processes like nervous system sensitization, brain changes, and immune system responses. Psychosocial factors add further challenges. Leading experts will discuss these processes and show how they affect clinical exams and treatments. By the end, attendees will gain new examination and treatment methods to improve patient outcomes, reducing pain and disability. With the ongoing pain and opioid crisis, clinicians must apply evidence-based, non-pharmacological strategies to manage chronic pain effectively.